|
KMID : 1134820220510040295
|
|
Journal of the Korean Society of Food Science and Nutrition
2022 Volume.51 No. 4 p.295 ~ p.301
|
|
|
Yulmu Herbal Tea Reduces Hepatic Lipid Accumulation by Upregulating p-AMPK Expression in C57BL/6 Mice
|
|
Yoo Gang-Wan
Park Hae-Jin
Cho Su-Jung
Lee Se-Hui
Park Soon-Ae
Kim Mi-Lim
|
|
|
Abstract
|
|
|
|
The present study investigated the hepatic lipid-lowering effect of Yulmu herbal tea mediated by regulating hepatic protein expressions. C57BL/6 mice were randomly divided into four groups: (1) normal (normal diet), (2) control (60% high-fat diet), (3) control＋Garcinia cambogia 200 mg/kg/d (GC), (4) control＋Yulmugambi water extract 200 mg/kg/d (YM200). Serum triglyceride (TG), total cholesterol (TC), and low-density lipoprotein concentrations significantly decreased in the GC and YM200 groups compared to the control group. There was also a significant reduction in the serum malondialdehyde levels in the GC and YM200 groups. The YM200 treatment significantly increased the hepatic phosphorylated-AMP-activated protein kinase (p-AMPK) expression, and inhibited the hepatic sterol regulatory element-binding protein-2 and 3-hydroxy-3-methylglutaryl coenzyme A reductase protein expressions, which are the key regulators of hepatic lipid synthesis. YM200 also significantly upregulated hepatic fatty acid oxidation proteins such as carnitine palmitoyltransferase 1 and uncoupling protein 2. Therefore, hepatic TG and TC levels and lipid droplets were suppressed in the YM200 group. YM200 reduced hepatic lipid accumulation and regulated hepatic lipid-relating protein expressions mediated by upregulating the p-AMPK expression. In conclusion, YM200 may be useful for regulating hepatic lipid metabolism and hepatic steatosis.
|
|
|
KEYWORD
|
|
|
Yulmu herbal tea, p-AMPK, hepatic lipid metabolism, C57BL/6 mice
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|